Over 33,000 cases of malignant cancer were recorded by Karachi Cancer Registry in the city over three years. This is an alarming situation, requiring immediate intervention at different levels. At an online public awareness seminar on "Cancer and Karachi Cancer Registry", Dr Shahid Pervez, Chairperson of the Karachi Cancer Registry and Professor at the Department of Pathology & Laboratory Medicine of the Aga Khan University Hospital in Karachi, stated: "Breast cancer is the leading cancer in Karachi followed by oral cancer, a largely preventable disease."